| Attribute | Detail |
|---|---|
| Format | Recorded Lectures |
| Level | Intermediate |
| Duration | 3 Days (60-90 minutes per session) |
| Certification | e-Certification + e-Marksheet |
| Fee | Free |
| Tools | PubChem SwissADME pkCSM ADMETlab ProTox-II Google Sheets Excel ChatGPT Gemini |
About the Hands-on In Silico ADMET Profiling, Drug-Likeness Screening and Toxicity Prediction for Lead Optimization Course
This 3‑day hands‑on course introduces participants to ADMET prediction, drug‑likeness screening, toxicity analysis, and lead compound prioritisation for computational drug discovery.
You will use PubChem, SwissADME, pkCSM, ADMETlab and ProTox‑II to evaluate pharmacokinetic properties, toxicity risks and drug‑like potential of selected compounds. Ideal for students, PhD scholars, researchers, academicians, pharma professionals, biotech learners and bio‑informatics enthusiasts.
Program Highlights
• Comprehensive coverage of Hands from fundamentals to advanced applications
• Hands-on projects and real-world case studies in Biotechnology
• Expert-curated curriculum aligned with current industry standards
• Access to recorded lectures and e-LMS platform for flexible, self-paced learning
• e-Certification and e-Marksheet upon successful completion
• Dedicated mentor support and interactive doubt-clearing sessions
• Practical experience with tools: PubChem, SwissADME, pkCSM, ADMETlab
• Career-oriented training for academic and professional growth in Biotechnology
Course Curriculum
Module 1: Day 1 – Introduction to ADMET & Drug‑Likeness Screening
- Understand the role of ADMET in drug discovery
- Explore Lipinski’s Rule of Five and lead‑likeness concepts
- Perform drug‑likeness evaluation with SwissADME
- Retrieve structures and SMILES from PubChem
Module 2: Day 2 – Pharmacokinetic Prediction & ADME Profiling
- Analyse absorption, distribution, metabolism and excretion (ADME) parameters
- Compare GI absorption, BBB permeation and solubility scores
- Interpret CYP enzyme interactions and P‑glycoprotein substrate/inhibitor status
- Generate comprehensive ADME profiles with pkCSM and ADMETlab
Module 3: Day 3 – Toxicity Prediction, Lead Prioritisation & Final Selection
- Predict acute toxicity, hepatotoxicity, mutagenicity and carcinogenicity with ProTox‑II
- Assess hERG inhibition and cardiotoxicity risk
- Interpret toxicity class and LD50 values
- Combine docking scores with ADMET/toxicity data for holistic ranking
Tools, Techniques, or Platforms Covered
PubChem SwissADME pkCSM ADMETlab ProTox-II Google Sheets Excel ChatGPT Gemini
Real-World Applications
- Apply Hands skills directly to academic research, thesis work, and publications
- Build a professional portfolio showcasing practical Biotechnology competencies
- Solve industry-relevant problems using Hands methodologies and tools
- Contribute to open-source projects and collaborative research in Biotechnology
- Prepare for competitive examinations, interviews, and professional certifications in Biotechnology
Who Should Attend & Prerequisites
- Industry‑recognised e‑Certification + e‑Marksheets from NSTC
- Hands‑on training with practical projects and industrial datasets
- Dedicated expert mentorship and doubt‑resolution sessions
Certification
